Crosstalk between tumor cells and the cognate microenvironment plays a crucial role in tumor initiation and progression. However, only a few genes are known to affect such a crosstalk. This study reveals that WSX1 plays such a role when highly expressed in tumor cells. The expression of WSX1 in Lewis Lung Carcinoma (LLC) and the melanoma cell line AGS induces the death of T cells and inhibits the production of the effector cytokine IFNγ from NK and T cells, resulting in the promotion of tumor growth. These pro-tumorigenic properties of WSX1 are independent of IL27. This key observation reveals a new pathway of tumor-host interaction, which will ultimately lead to better strategies in immune therapy to reverse tumor tolerance. © 2011 Dibra et al.
Dibra, D., Cutrera, J., Xia, X., & Li, S. (2011). Wsx1 expression in tumors induces immune tolerance via suppression of effector immune cells. PLoS ONE, 6(4). https://doi.org/10.1371/journal.pone.0019072