In this issue of Immunity, Zhu et al. (2017) report that tumor-associated macrophages in a mouse model of pancreatic ductal adenocarcinoma (PDAC) originate from both the yolk sac (YS) and bone marrow. Differential ablation of these populations indicates that only the YS-derived macrophages promote PDAC progression and growth.
Pollard, J. W. (2017, August 15). The Yolk Sac Feeds Pancreatic Tumors. Immunity. Cell Press. https://doi.org/10.1016/j.immuni.2017.07.021