Yttrium-90 Radioembolization for Colorectal Cancer Liver Metastases: A Single Institution Experience

  • Nace G
  • Steel J
  • Amesur N
  • et al.
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Abstract

Purpose . We sought to evaluate our experience using yttrium-90 ( 90 Y) resin microsphere hepatic radioembolization as salvage therapy for liver-dominant metastatic colorectal cancer (mCRC). Methods . A retrospective review of consecutive patients with unresectable mCRC who were treated with 90 Y after failing first and second line systemic chemotherapy. Demographics, treatment dose, biochemical and radiographic response, toxicities, and survival were examined. Results . Fifty-one patients underwent 90 Y treatments of which 69% were male. All patients had previously undergone extensive chemotherapy, 31% had undergone previous liver-directed therapy and 24% had a prior liver resection. Using RECIST criteria, either stable disease or a partial response was seen in 77% of patients. Overall median survival from the time of first 90 Y treatment was 10.2 months (95% CI = 7.5–13.0). The absence of extrahepatic disease at the time of treatment with 90 Y was associated with an improved survival, median survival of 17.0 months (95% CI = 6.4–27.6), compared to those with extrahepatic disease at the time of treatment with 90 Y, 6.7 months (95% CI = 2.7–10.6 Conclusion: 90 Y therapy is a safe locoregional therapy that provides an important therapeutic option to patients who have failed first and second line chemotherapy and have adequate liver function and performance status.

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Nace, G. W., Steel, J. L., Amesur, N., Zajko, A., Nastasi, B. E., Joyce, J., … Gamblin, T. C. (2011). Yttrium-90 Radioembolization for Colorectal Cancer Liver Metastases: A Single Institution Experience. International Journal of Surgical Oncology, 2011, 1–9. https://doi.org/10.1155/2011/571261

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