Zebrafish as Toxicological model for screening and recapitulate human diseases

  • Caballero M
  • Candiracci M
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Abstract

Embryonic and larval Danio rerio is increasingly used as a toxicological model to conduct rapid in vivo tests and developmental toxicity assays; the zebrafish features as high genetic homology to mammals; robust phenotypes; and its value in high-throughput genetic and chemical screening have made it a powerful tool to evaluate in vivo toxicity. New methodologies of genome editing as CRISPR/Cas9; ZFN or Talen make it a suitable model to perform studies to pair human genetic diseases as well. This review surveys recent studies; employing zebrafish as experimental model; comparing it with other in vivo and in vitro models; presenting zebrafish as a potent vertebrate tool to evaluate drug toxicity to facilitate more extensive; easy and comprehensive knowledge of new generation drugs.

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Caballero, M. V., & Candiracci, M. (2018). Zebrafish as Toxicological model for screening and recapitulate human diseases. Journal of Unexplored Medical Data, 3(2), 4. https://doi.org/10.20517/2572-8180.2017.15

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