Zip2, a meiosis-specific protein required for the initiation of chromosome synapsis

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Abstract

We describe the identification and characterization of the Saccharomyces cerevisiae ZiP2 gene, which encodes a novel meiosis-specific protein essential for synaptonemal complex formation. In the zip2 mutant, chromosomes are homologously paired but not synapsed. The Zip2 protein localizes to discrete foci on meiotic chromosomes; these foci correspond to sites of convergence between paired homologs that are believed to be sites of synapsis initiation. Localization of Zip2p requires the initiation of meiotic recombination. In a mutant defective in double-strand break repair, Zip2p colocalizes with proteins involved in double-strand break formation and processing. We propose that Zip2p promotes the initiation of chromosome synapsis and that localization of Zip2p to sites of interhomolog recombination ensures synapsis between homologous chromosomes.

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Chua, P. R., & Roeder, G. S. (1998). Zip2, a meiosis-specific protein required for the initiation of chromosome synapsis. Cell, 93(3), 349–359. https://doi.org/10.1016/S0092-8674(00)81164-2

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