ZnO nanoparticles augment ALT, AST, ALP and LDH expressions in C2C12 cells

7Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.

Abstract

The present study aimed to investigate the effect of ZnO nanoparticles on alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) enzyme expressions in C2C12 cells. ZnO nanoparticles are widely used in the several cosmetic lotions and other biomedical products. Several studies report on ZnO nanoparticle mediated cytotoxicity. However, there are no reports on the effect of ZnO nanoparticles on ALT, AST, ALP and LDH enzyme expressions in C2C12 cells. A cytotoxicity assay was carried out to determine the effect of ZnO nanoparticles (1-5. mg/ml) on C2C12 cell viability at 48 and 72. h. ZnO nanoparticles increased ALT, AST, ALP and LDH enzyme mRNA expression and their activities in C2C12 cells. In conclusion, the present study showed that ZnO nanoparticles increased these enzyme activities and its mRNA expression in C2C12 cells in a dose-dependent manner.

Cite

CITATION STYLE

APA

Pandurangan, M., & Kim, D. H. (2015). ZnO nanoparticles augment ALT, AST, ALP and LDH expressions in C2C12 cells. Saudi Journal of Biological Sciences, 22(6), 679–684. https://doi.org/10.1016/j.sjbs.2015.03.013

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free