α1-Microglobulin as a promising marker of cadmium-induced tubular dysfunction, possibly better than β2-microglobulin

  • Moriguchi J
  • Ezaki T
  • Tsukahara T
 et al. 
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Abstract

The purpose of the present study was to evaluate the validity of α1-microglobulin (α1-MG) in comparison with popularly used β2-microglobulin (β2-MG). A database on 8975 cases of never-smoking adult women was revisited; the data were based on spot urine samples from the women in 10 prefectures all over Japan. The validity of α1-MG was examined following essentially the same protocol as β2-MG was examined in a previous study. Comparisons were made for α1-MG as observed (e.g. α1-MGob), as corrected for creatinine (CR or cr) (e.g. α1-MGcr) and as corrected for a specific gravity (SG or sg) of 1.016 (e.g. α1-MGsg). A cut-off value of 5.0mg α1-MG/g cr or l was deduced from 400μg β2-MG/g cr taking advantage of the regression equation between α1-MG and β2-MG. The prevalence of α1-microglobulinuria as corrected for a specific gravity of 1.016 (or α1-MGsg-uria in short) was essentially unchanged irrespective of SG, except for in very dense or very thin urine samples. α1-MGcr-uria prevalence decreased at higher CR. Comparison of the present observation with previous findings on β2-MG-uria prevalence showed that the variation in prevalence of MG-uria as a function of urine density was smaller for α1-MGsgwhereas it was substantially larger for β2-MGcr, and thus it appeared prudent to consider α1-MGsgrather than β2-MGcras a marker of tubular dysfunction. © 2003 Elsevier Ireland Ltd. All rights reserved.

Author-supplied keywords

  • Adult women
  • Cadmium
  • General population
  • Urine density
  • α1-Microglobulin
  • β2-Microglobulin

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Authors

  • J. Moriguchi

  • T. Ezaki

  • T. Tsukahara

  • K. Furuki

  • Y. Fukui

  • S. Okamoto

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