β-Bungarotoxin inhibits a non-inactivating potassium current in guinea pig dorsal root ganglion neurones

  • Petersen M
  • Penner R
  • Pierau F
 et al. 
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Abstract

β-Bungarotoxin (β-BuTx), at concentrations of 0.45-45 nmol/l, selectively reduced a portion of the non-inactivating potassium current (Isk) in dorsal root ganglion neurones of the guinea pig, measured by voltage clamp of internally perfused cells. The average reduction of Iskobtainable with β-BuTx was 34% and usually not completed within 20 min, but irreversible upon washing for 20 min. The I/V-characteristic of the current blocked by β-BuTx was almost linear. It is suggested that β-BuTx selectively blocks a non-inactivating subtype of potassium channel. © 1986.

Author-supplied keywords

  • dendrotoxin
  • dorsal root ganglion
  • potassium channel
  • β-bungarotoxin

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Authors

  • M. Petersen

  • R. Penner

  • Fr K. Pierau

  • F. Dreyer

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