β-Bungarotoxin inhibits a non-inactivating potassium current in guinea pig dorsal root ganglion neurones

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Abstract

β-Bungarotoxin (β-BuTx), at concentrations of 0.45-45 nmol/l, selectively reduced a portion of the non-inactivating potassium current (Isk) in dorsal root ganglion neurones of the guinea pig, measured by voltage clamp of internally perfused cells. The average reduction of Isk obtainable with β-BuTx was 34% and usually not completed within 20 min, but irreversible upon washing for 20 min. The I/V-characteristic of the current blocked by β-BuTx was almost linear. It is suggested that β-BuTx selectively blocks a non-inactivating subtype of potassium channel. © 1986.

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Petersen, M., Penner, R., Pierau, F. K., & Dreyer, F. (1986). β-Bungarotoxin inhibits a non-inactivating potassium current in guinea pig dorsal root ganglion neurones. Neuroscience Letters, 68(1), 141–145. https://doi.org/10.1016/0304-3940(86)90244-2

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