β-Endorphin-induced increases in plasma epinephrine, norepinephrine and dopamine in rats: inhibition of adrenomedullary response by intracerebral somatostatin

  • Van Loon G
  • Appel N
  • Ho D
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Abstract

Synthetic human β-endorphin, 7.25 nmol intracisternally, in unanesthetized, freely moving, chronically cannulated, adult male rats increased plasma concentrations of all 3 catecholamines: epinephrine, norepinephrine and dopamine, for the 2 h period studied. Blockade of these endorphin effects by the prior systemic administration of naloxone supports mediation of the effects at opioid receptors. Acute systemic administration of guanethidine, which decreases norepinephrine release induced by sympathetic nerve stimulation, blunted the plasma norepinephrine response to intracerebral β-endorphin. Thus, it seems likely that in addition to secretion by adrenal medulla a considerable portion of the β-endorphin-induced increase in norepinephrine is derived from sympathetic nerve endings. Simultaneous intracisternal administration of another neuropeptide, somatostatin, together with β-endorphin markedly inhibited the plasma epinephrine response to β-endorphin, while decreasing the dopamine and norepinephrine responses to a much lesser degree. The data suggest that β-endorphin stimulates central sympathetic outflow to both adrenal medulla and sympathetic nerve endings, and further that somatostatin inhibits the effect of endorphin to stimulate outflow to adrenal medulla but does not affect outflow to sympathetic nerve endings. © 1981.

Author-supplied keywords

  • central sympathetic outflow
  • intracisternal
  • naloxone
  • opioid
  • β-endorphin

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Authors

  • Glen R. Van Loon

  • Nathan M. Appel

  • Doris Ho

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