13C bis-labeled pyrroles: A tool for the identification of the rat metabolism of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester

  • Micheli F
  • Cavanni P
  • Fabio R
 et al. 
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Abstract

Following the recent disclosure of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester as a potent and selective mGluR1 non-competitive antagonist, the use of a doubly13C-labeled analogue to identify, and consequently prevent, metabolically labile positions is reported. © 2006 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Glutamate
  • Metabolism
  • Metabotropic
  • mGluR1

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Authors

  • Fabrizio Micheli

  • Paolo Cavanni

  • Romano Di Fabio

  • Daniele Donati

  • Mahmoud Hamdan

  • Stefano Provera

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