13C bis-labeled pyrroles: A tool for the identification of the rat metabolism of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester

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Abstract

Following the recent disclosure of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester as a potent and selective mGluR1 non-competitive antagonist, the use of a doubly 13C-labeled analogue to identify, and consequently prevent, metabolically labile positions is reported. © 2006 Elsevier Ltd. All rights reserved.

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Micheli, F., Cavanni, P., Fabio, R. D., Donati, D., Hamdan, M., Provera, S., … Vitulli, G. (2007). 13C bis-labeled pyrroles: A tool for the identification of the rat metabolism of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester. Bioorganic and Medicinal Chemistry Letters, 17(4), 969–973. https://doi.org/10.1016/j.bmcl.2006.11.039

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