Acceptor site recognition of transglycosylase inhibitors A β-D- glucopyranosyl-(1 → 2)-α-D-glucopyranuronamide-derived moenomycin analogue

  • Ferse F
  • Floeder K
  • Hennig L
 et al. 
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Abstract

The synthesis, the antibiotic and the transglycosylase inhibiting properties of a disaccharide analogue of moenomycin A in which the NHAc group of unit E is replaced by a hydroxyl function are described. It can be concluded that this NHAc group is essential for eliciting transglycosylase inhibiting properties, in agreement with a recently established solution structure of moenomycin A.

Author-supplied keywords

  • Antibiotics
  • Carbohydrates
  • Phospholipids
  • Structure-activity

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Authors

  • Falk Thilo Ferse

  • Kerstin Floeder

  • Lothar Hennig

  • Matthias Findeisen

  • Peter Welzel

  • Dietrich Müller

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