Acetylcholine stimulates phosphatidylinositol turnover at nicotinic receptors of cultured myotubes

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Abstract

Acetylcholine treatment of [3H]inositol pre-labelled cultured chick embryo myotubes results in the stimulation of phosphatidylinositol breakdown, as shown by the measurement of inositol-1-phosphate accumulating in the presence of lithium. The described effect is dependent on agonist concentration and incubation time, and is inhibited by tubocurarine and α-bungarotoxin. The activation of phosphatidylinositol breakdown by acetylcholine at extrajunctional nicotinic receptors is likely to be involved in the modulation of the functional activity of the receptor. © 1985.

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Adamo, S., Zani, B. M., Nervi, C., Senni, M. I., Molmaro, M., & Eusebi, F. (1985). Acetylcholine stimulates phosphatidylinositol turnover at nicotinic receptors of cultured myotubes. FEBS Letters, 190(1), 161–164. https://doi.org/10.1016/0014-5793(85)80449-X

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