Acetylcholine stimulates phosphatidylinositol turnover at nicotinic receptors of cultured myotubes

  • Adamo S
  • Zani B
  • Nervi C
 et al. 
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Acetylcholine treatment of [3H]inositol pre-labelled cultured chick embryo myotubes results in the stimulation of phosphatidylinositol breakdown, as shown by the measurement of inositol-1-phosphate accumulating in the presence of lithium. The described effect is dependent on agonist concentration and incubation time, and is inhibited by tubocurarine and α-bungarotoxin. The activation of phosphatidylinositol breakdown by acetylcholine at extrajunctional nicotinic receptors is likely to be involved in the modulation of the functional activity of the receptor. © 1985.

Author-supplied keywords

  • Acetylcholine
  • Cultured myotube
  • Nicotinic receptor
  • Phosphoinositide
  • Receptor modulation

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