Acidification of water and extrahepatic biotransformation in fish

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The effects of decreased aquatic pH on the extrahepatic biotransformation reactions in fish were studied. Fishes were exposed to water of pH 3 for 8 h and extrahepatic biotransformation was monitored by measuring renal and duodenal activities of ethoxycoumarin O-deethylase, epoxide hydrase, aryl hydrocarbon hydroxylase and UDP-glucuronosyltransferase. The activities were analysed at 18°C and 25°C. In the kidney the activities of ethoxycoumarin O-deethylase and epoxide hydrase were increased with acidic water while the opposite was true with aryl hydrocarbon hydroxylase. In acidic water ethoxycoumarin O-deethylase also showed a tendency to increase in duodenal mucosa. © 1984.




Laitinen, M., Hietanen, E., Nieminen, M., & Pasanen, P. (1984). Acidification of water and extrahepatic biotransformation in fish. Environmental Pollution. Series A, Ecological and Biological, 35(3), 271–278.

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