Acidification of water and extrahepatic biotransformation in fish

  • Laitinen M
  • Hietanen E
  • Nieminen M
 et al. 
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The effects of decreased aquatic pH on the extrahepatic biotransformation reactions in fish were studied. Fishes were exposed to water of pH 3 for 8 h and extrahepatic biotransformation was monitored by measuring renal and duodenal activities of ethoxycoumarin O-deethylase, epoxide hydrase, aryl hydrocarbon hydroxylase and UDP-glucuronosyltransferase. The activities were analysed at 18°C and 25°C. In the kidney the activities of ethoxycoumarin O-deethylase and epoxide hydrase were increased with acidic water while the opposite was true with aryl hydrocarbon hydroxylase. In acidic water ethoxycoumarin O-deethylase also showed a tendency to increase in duodenal mucosa. © 1984.

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  • Matti Laitinen

  • Eino Hietanen

  • Mauri Nieminen

  • Pentti Pasanen

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