1. The effects of resin acids on the development of, and recovery from jaundice in rainbow trout were studied. 2. At 0.4 mg/1 or higher resin acid concentration, fish developed jaundice in 2-4 days at water temperatures over 17??C and recovered from severe intoxication within 6 days. 3. Jaundice results at least partially from insufficient secretion of conjugated bilirubin into the bile, probably because resin acids and bilirubin share a common secretion pathway. 4. The activity of liver UDP-glucuronosyltransferase and concentration of plasma bilirubin are sensitive indicators of the exposure of trout to discharges containing resin acids. ?? 1987.
Mattsoff, L., & Oikari, A. (1987). Acute hyperbilirubinaemia in rainbow trout (Salmo gairdneri) caused by resin acids. Comparative Biochemistry and Physiology. Part C, Comparative, 88(2), 263–268. https://doi.org/10.1016/0742-8413(87)90120-4