Acute lymphoblastic leukaemia in adults: Clinicopathological correlations with the French-American-British (FAB) co-operative group classification

Abstract

The clinical, haematological and cell surface marker findings in 54 adults with acute lymphoblastic leukaemia have been correlated with the French-American-British (FAB) co-operative group classification of acute leukaemias. A significant relationship (P = 0.03) was found between Burkitt-like cytology, (FAB) L3 and Central Nervous System (CNS) disease at clinical and haematological remission. The incidence of primary CNS relapse was significantly greater in the FAB, L1 group than L2 (P = 0.03). The classification did not predict for differences in haematological or cell surface marker findings. There was also no apparent correlation with the rate or duration of complete remission. © 1979.