Alterations in components of the pineal melatonin synthetic pathway by acute insulin stress in the rat and Syrian hamster

  • Champney T
  • Steger R
  • Christie D
 et al. 
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Abstract

Acute insulin stress increased plasma catecholamine levels in both the Syrian hamster and albino rat within 3 h after an intraperitoneal injection of either 5 or 10 units of insulin. In the rat, this stress caused a concurrent increase in pineal serotonin N-acetyltransferase (NAT) activity and melatonin content with no observable change in hydroxyindole-O-methyltransferase (HIOMT) activity. In the hamster, on the other hand, acute insulin stress did not alter pineal NAT activity, but depressed both HIOMT activity and melatonin content up to 3 h after the stress. These results present further evidence that catecholamines do not control hamster pineal melatonin synthesis by the same mechanism as observed in the rat. © 1985.

Author-supplied keywords

  • Syrian hamster
  • albino rat
  • catecholamines
  • melatonin
  • pineal
  • stress

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Authors

  • Thomas H. Champney

  • Richard W. Steger

  • Douglas S. Christie

  • Russel J. Reiter

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