In this paper we describe the use of macroporous, highly cross-linked poly(styrene-divinylbenzene) as a base matrix for solid phase scavengers. We demonstrate that this matrix is superior to the more traditional Merrifield resins when non-swelling solvents like acetonitrile are used. A small library of sulfonamides is generated in high purity as an example. (C) 2000 Elsevier Science Ltd.
Nicewonger, R. B., Ditto, L., & Varady, L. (2000). Alternative base matrices for solid phase quenching reagents. Tetrahedron Letters, 41(14), 2323–2326. https://doi.org/10.1016/S0040-4039(00)00192-1