Alternative base matrices for solid phase quenching reagents

  • Nicewonger R
  • Ditto L
  • Varady L
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Abstract

In this paper we describe the use of macroporous, highly cross-linked poly(styrene-divinylbenzene) as a base matrix for solid phase scavengers. We demonstrate that this matrix is superior to the more traditional Merrifield resins when non-swelling solvents like acetonitrile are used. A small library of sulfonamides is generated in high purity as an example. (C) 2000 Elsevier Science Ltd.

Author-supplied keywords

  • Polymer support
  • Solid-supported reactions
  • Sulfonamides
  • Supported reagents

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Authors

  • Robert B. Nicewonger

  • Lori Ditto

  • Laszlo Varady

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