Amino-terminally truncated desmin rescues fusion of des-/-myoblasts but negatively affects cardiomyogenesis and smooth muscle development

  • Höllrigl A
  • Puz S
  • Al-Dubai H
 et al. 
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Abstract

Desmin fulfils important functions in maintenance of muscle cells and mutations in the desmin gene have been linked to a variety of myopathies. To ascertain the role of desmin's amino-terminal domain in muscle cells we generated embryonic stem cells constitutively expressing desminΔ1-48in a null background and investigated muscle cell development in vitro. DesminΔ1-48lacking the first 48 amino acid residues promotes fusion of myoblasts, rescues myogenesis and down-regulates vimentin expression in embryoid bodies, but hampers cardiomyogenesis and blocks smooth muscle development. These results demonstrate that desmin's amino-terminus has different roles in skeletal, cardiac, and smooth muscle cell development and function. © 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

Author-supplied keywords

  • Cardiomyogenesis
  • Desmin
  • In vitro differentiation
  • Muscle development

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Authors

  • Kings of DubaiEscorts in Dubai

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  • Alexandra Höllrigl

  • Sonja Puz

  • Jai Up Kim

  • Yassemi Capetanaki

  • Georg Weitzer

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