Mineralocorticoid activity of 19-hydroxyandrost-4-ene-3, 17-dione was evaluated by mineralocorticoid bioassays using adrenalectomized rats. 19-Hydroxyandrost-4-ene-3, 17-dione was devoid of mineralocorticoid activity. However, it caused a significant decrease in urinary Na K ratio and Na excretion and a significant increase in urinary K excretion when it was administered simultaneously with subthreshold doses of aldosterone. The results demonstrate that 19-hydroxyandrost-4-ene-3, 17-dione amplified the action of subthreshold doses of aldosterone. © 1979.
Sekihara, H., Ohsawa, N., & Kosaka, K. (1979). Amplification of the action of subthreshold doses of aldosterone by 19-Hydroxyandrost-4-ene-3, 17-dione. Biochemical and Biophysical Research Communications, 87(3), 827–835. https://doi.org/10.1016/0006-291X(79)92032-1