Amplification of the action of subthreshold doses of aldosterone by 19-Hydroxyandrost-4-ene-3, 17-dione

  • Sekihara H
  • Ohsawa N
  • Kosaka K
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Mineralocorticoid activity of 19-hydroxyandrost-4-ene-3, 17-dione was evaluated by mineralocorticoid bioassays using adrenalectomized rats. 19-Hydroxyandrost-4-ene-3, 17-dione was devoid of mineralocorticoid activity. However, it caused a significant decrease in urinary Na K ratio and Na excretion and a significant increase in urinary K excretion when it was administered simultaneously with subthreshold doses of aldosterone. The results demonstrate that 19-hydroxyandrost-4-ene-3, 17-dione amplified the action of subthreshold doses of aldosterone. © 1979.

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  • Hisahiko Sekihara

  • Nakaaki Ohsawa

  • Kinori Kosaka

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