Models for repeated measures cross-over designs are defined in terms of growth curve models. In the paper two specific cross-over designs, called the AB:BA and ABAB:BABA design, are studied. The maximum-likelihood (ML) estimators for the parameters are derived by utilizing the theory for growth curve models. A model with a structured dispersion matrix is defined for the AB:BA design, and a specific linear transformation is used to derive estimators in a convenient way. To illustrate numerically, ML estimates are calculated for an ABAB:BABA study. © 2004 Published by Elsevier B.V.
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