Analytical techniques in dissolution testing and bioavailability studies

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Abstract

The rate and extent of absorption of a drug into the bloodstream is an important quality characteristic of a dosage form. In vivo bioavailability and in vitro dissolution studies are important in the development and ultimately in the quality control of a dosage form. The integrity of these tests is dependent on the analytical methods used. The advent of very potent drugs used in low dosage and the development of novel drug delivery systems require that the most sophisticated methods are used. This paper surveys recent trends in analytical advances that are useful in dissolution and bioavailability testing and suggests some future directions. © 1987.

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Munson, J. W. (1986). Analytical techniques in dissolution testing and bioavailability studies. Journal of Pharmaceutical and Biomedical Analysis, 4(6), 717–724. https://doi.org/10.1016/0731-7085(86)80082-6

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