Antagonism of morphine-induced behavioral suppression by opiate receptor alkylators

9Citations
Citations of this article
2Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Experiments were conducted to test the in vivo opiate specificity and long-lasting effects of two non-equilibrium opiate antagonists: β-chlornaltrexamine (β-CNA) and the β-fumarate methyl ester derivative of naltrexone (β-FNA). β-CNA (2.5 or 5.0 μg, ICV) partially antagonized suppression of conditioned autoshaped behavior by morphine, when morphine was administered 48-72 hr after β-CNA. β-CNA had no effect on amphetamine-induced suppression of autoshaped responding, nor did it antagonized the suppression in rearing activity induced by either morphine or amphetamine. Similarly, β-FNA (5 mg/kg, IP) antagonized the suppression of conditioned behavior by morphine, for up to 48 hr, while having no effect on amphetamine-induced suppression of autoshaped responding, or on the suppression of rearing activity induced by morphine or amphetamine. Further peripherally administered β-FNA acts in the brain, since it antagonized analgesia following ICV morphine administration. © 1982.

Cite

CITATION STYLE

APA

Messing, R. B., Portoghese, P. S., Takemori, A. E., & Sparber, S. B. (1982). Antagonism of morphine-induced behavioral suppression by opiate receptor alkylators. Pharmacology, Biochemistry and Behavior, 16(4), 621–626. https://doi.org/10.1016/0091-3057(82)90426-9

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free