Antiemetic effects of sendide, a peptide tachykinin NK1receptor antagonist, in the ferret

  • Minami M
  • Endo T
  • Kikuchi K
 et al. 
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Abstract

The antiemetic activity of sendide, a new peptide tachykinin NK1receptor antagonist, against cisplatin-induced emesis was investigated using ferrets. The frequency of cisplatin (10 mg/kg, i.p.)-induced retching (104.6±14.3/6 h) and vomiting (19.0±3.0/6 h) was significantly reduced by pretreatment with sendide (3.0 mg/kg, s.c.) (14.0±8.1/6 h and 1.8±1.2/6 h, respectively). Intravenous bolus injection of substance P (1-10 μg/kg) or 5-hydroxytryptamine (5-HT) (10-50 μg/kg) produced a dose-dependent increase in the abdominal afferent vagus nerve activity. The change from pre-injection level in the afferent nerve activity induced by substance P (1 μg/kg, i.v.) (453.7±51.5%) was significantly reduced by pretreatment with either sendide (100 μg/kg, i.v.) (276.1±50.1%, P

Author-supplied keywords

  • Abdominal afferent vagus nerve activity
  • Antiemetic activity
  • Cisplatin
  • Sendide
  • Tachykinin NK1receptor antagonist

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Authors

  • Masaru Minami

  • Toru Endo

  • Kazuhiko Kikuchi

  • Emi Ihira

  • Masahiko Hirafuji

  • Naoya Hamaue

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