The antinociceptive effect of morphine is reversed by okadaic acid in morphine-naive but not in morphine-tolerant mice

3Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The activation of specific subtypes of serine/threonine protein phosphatases (PPs) plays a role in the antinociceptive effect of acute morphine, but it is not known whether these enzymes are involved in morphine-induced antinociception in morphine-tolerant animals. We evaluated the effects of both okadaic acid (a selective inhibitor of some serine/threonine PPs) and its inactive analogue L-norokadaone on the antinociception induced by morphine in morphine-naive and -tolerant female mice in the tail-flick test. Okadaic acid (0.01 and 1 pg/mouse, i.c.v.), but not L-norokadaone (1 pg/mouse, i.c.v.), antagonized in a dose-dependent way the antinociception induced by morphine (1-16 mg/kg, s.c.) in morphine-naive animals. However, both okadaic acid (0.01 and 1 pg/mouse, i.c.v.) and L-norokadaone (1 pg/mouse, i.c.v.) were unable to modify the antinociceptive effect of morphine in morphine-tolerant mice. These results suggest that in morphine-induced thermal analgesia, the role of serine/threonine PPs highly sensitive to okadaic acid is different in morphine-tolerant and morphine-naive female mice. © 2007 Elsevier Inc. All rights reserved.

Cite

CITATION STYLE

APA

Ocaña, M., Entrena, J. M., Baeyens, J. M., & Del Pozo, E. (2007). The antinociceptive effect of morphine is reversed by okadaic acid in morphine-naive but not in morphine-tolerant mice. Pharmacology Biochemistry and Behavior, 86(1), 21–26. https://doi.org/10.1016/j.pbb.2006.12.002

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free