Antioxidant characteristics of some potential anticataract agents. Studies of aspirin, paracetamol, and bendazac provide support for an oxidative component of cataract

  • Woollard A
  • Wolff S
  • Bascal Z
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Abstract

It is conceivable that drugs with anticataract potential possess antioxidant activity. Using defined chelating agents and reducing agents in a number of assays for antioxidant activity, we have deomstrated that paracetamol, aspirin, bendazac, and its metabolite 5-hydroxybendazac possess substantial reducing and/or metal-chelating activity. We found that paracetamol and 5-hydroxybendazac reduced the dipehenylpicrylhydrazyl free radical; inhibited butyl peroxide-induced erythrocyte lysis as well as the haematin-catalyzed oxidative couling of 4-aminoantipyrine and phenol by butyl peroxide. Furthermore, paracetamol, bendazac, and aspirin competed with 3-(2-pyridyl)-5,6-Diphenyl-1,2,4-triazine-4′,4′'-disulphonic acid (ferrozine) for ferrous ion. © 1990.

Author-supplied keywords

  • Antioxidant
  • Cataract
  • Free radicals
  • Oxidative stress

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Authors

  • Alison C.S. Woollard

  • Simon P. Wolff

  • Zainab A. Bascal

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