An approach to oxazolidin-2-ones from the Baylis-Hillman adducts. Formal synthesis of a chloramphenicol derivative

  • Coelho F
  • Rossi R
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Abstract

In this communication we describe a straightforward and diastereoselective approach to prepare functionalised oxazolidin-2-ones from Baylis-Hillman adducts. A stereoselective synthesis of a highly substituted vicinal aminoalcohol and a formal synthesis of a chloramphenicol derivative are also described. © 2002 Elsevier Science Ltd. All rights reserved.

Author-supplied keywords

  • Baylis-Hillman reaction
  • Chloramphenicol derivative
  • Oxazolidin-2-one

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Authors

  • Fernando Coelho

  • Rodrigo C. Rossi

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