Articular cartilage, blood serum glycosaminoglycans and glycoproteins in osteoarthritis deformans

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Abstract

Glyeosaminoglycans in articular cartilage from human femoral heads have been isolated and fractionated by means of a cellulose microscale technique. The glucosaminoglycans have been identified by different procedures as keratan sulphate, hyaluronic acid, heparitin sulphate, chondroitin 4-sulphate, chondroitin 6-sulphate and dermatan sulphate. Osteoarthritic cartilage showed a significant reduction of dermatan sulphate, chondroitin 6-sulphate, keratan sulphate and heparitin sulphate. The content of glycoprotein carbohydrate components in the cartilage (neuraminic acid derivatives, hexoses, 6-deoxyhexoses) also appeared to be reduced. It has been shown that chondroitin 4-sulphate, keratan sulphate and dermatan sulphate content was considerably increased in osteoarthritic serum. Among serum glycoprotein carbohydrate constituents only the content of 6-deoxyhexoses was slightly increased. © 1979.

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Yusipova, N. A., & Kriuk, A. S. (1979). Articular cartilage, blood serum glycosaminoglycans and glycoproteins in osteoarthritis deformans. Clinica Chimica Acta, 94(1), 9–21. https://doi.org/10.1016/0009-8981(79)90181-5

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