With the aid of in vivo whole-body counting of the rats (administered simultaneously with the radionuclides82Br and24Na) by high-resolution gamma-ray spectrometry, we extended the applicability of our experimentally proved hypothesis that the biological half-life of bromide depends on the magnitude of sodium intake rather than on the intake of chloride, as was generally assumed. Variations in the biological half-life of bromide, as a substitute for sodium, were investigated in animals situated in very different physiological states, as regards their metabolic activity. © 2009 Elsevier Ltd. All rights reserved.
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