Assessment of drug-induced immunotoxicity in animal models

  • van Wijk F
  • Nierkens S
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Abstract

With the growing understanding that drugs might induce immune-mediated adverse reactions in patients, immunotoxicity testing of new pharmaceuticals has become an important topic in drug development. The nonclinical assessment of unexpected immune suppression is based on relatively well-standardized and validated assays and animal models. For the evaluation of direct immune stimulation few animal models are available, whilst the development of animal models to assess drug-induced hypersensitivity and in particular autoimmunity is in its infancy. © 2006 Elsevier Ltd. All rights reserved.

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