Assessment of unscheduled DNA synthesis in Fischer 344 rat pachytene spermatocytes exposed to caprolactam or benzoin in vivo

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Abstract

Male Fischer 344 rats were treated with the non-carcinogenic chemicals CAP and ZOIN. The spermatogenic cells were isolated at selected times post-exposure for assessment of chemically-induced DNA damage by quantitative autoradiography of unscheduled DNA synthesis (UDS). Neither chemical (750 mg/kg administered by gavage) induced UDS in pachytene spermatocytes isolated 12, 24 or 48 h after treatment. © 1989.

Author-supplied keywords

  • Benzoin
  • Caprolactam
  • DNA damage, chemically-induced
  • DNA synthesis, unscheduled
  • Unscheduled DNA synthesis

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Authors

  • Peter K. Working

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