Assessment of unscheduled DNA synthesis in Fischer 344 rat pachytene spermatocytes exposed to caprolactam or benzoin in vivo

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Abstract

Male Fischer 344 rats were treated with the non-carcinogenic chemicals CAP and ZOIN. The spermatogenic cells were isolated at selected times post-exposure for assessment of chemically-induced DNA damage by quantitative autoradiography of unscheduled DNA synthesis (UDS). Neither chemical (750 mg/kg administered by gavage) induced UDS in pachytene spermatocytes isolated 12, 24 or 48 h after treatment. © 1989.

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Working, P. K. (1989). Assessment of unscheduled DNA synthesis in Fischer 344 rat pachytene spermatocytes exposed to caprolactam or benzoin in vivo. Mutation Research/Genetic Toxicology, 224(3), 365–368. https://doi.org/10.1016/0165-1218(89)90181-X

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