Association among retinol-binding protein 4, small dense LDL cholesterol and oxidized LDL levels in dyslipidemia subjects

  • Wu J
  • Shi Y
  • Niu D
 et al. 
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Abstract

Objectives: To investigate retinol-binding protein 4 (RBP4), small dense low-density lipoprotein cholesterol (sdLDL-C) and oxidized low-density lipoprotein (ox-LDL) levels and their associations in dyslipidemia subjects. Design and methods: We determined RBP4, sdLDL-C, ox-LDL levels in 150 various dyslipidemia subjects and 50 controls. The correlation analysis and multiple linear regression analysis were performed. Results: The RBP4, sdLDL-C and ox-LDL levels were found increased in various dyslipidemia subjects. The sdLDL-C levels were positively correlated with RBP4 (r=0.273, P=0.001) and ox-LDL (r=0.273, P=0.001). RBP4 levels were also correlated with ox-LDL (r=0.167, P=0.043). The multiple regression analysis showed that only sdLDL-C was a significant independent predictor for RBP4 (β coefficient=0.219, P=0.009; adjusted R2=0.041) and ox-LDL (β coefficient=0.253, P=0.003; adjusted R2=0.057) levels, respectively. Conclusions: The independent associations of sdLDL-C with RBP4 and ox-LDL were observed in dyslipidemia subjects. RBP4 may play an important role in lipid metabolism of atherosclerosis, particularly in formation of sdLDL. © 2012 The Canadian Society of Clinical Chemists.

Author-supplied keywords

  • Atherosclerosis
  • Dyslipidemias
  • Oxidized LDL
  • Retinol-binding protein 4
  • Small dense LDL

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Authors

  • Jia Wu

  • Yong hui Shi

  • Dong mei Niu

  • Han qing Li

  • Chun ni Zhang

  • Jun jun Wang

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