Several susceptibility loci for both of schizophrenia and bipolar disorder (BPD) have been found to overlap on several chromosomes including 8p21. Expression of dihydropyrimidinase-related protein 2 (DRP-2), which gene is located on 8p21, was found to be reduced in the brains of individuals with schizophrenia and BPD. Recently, we demonstrated a significant association between the DRP-2 gene and schizophrenia. Based on the rationale, we investigated the genetic association of the DRP-2 gene with BPD using a case-control study in the Japanese population. However, no significant associations were found between five polymorphisms of the DRP-2 gene (-975C>G, 352G>A, 426C>T, 1506T>C, and *2236T>C), and BPD, nor were associations detected between either of the polymorphisms and any subtype of BPD, bipolars I and II. The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD. © 2003 Published by Elsevier Ireland Ltd.
Nakata, K., Ujike, H., Tanaka, Y., Takaki, M., Sakai, A., Nomura, A., … Kuroda, S. (2003). No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans. Neuroscience Letters, 349(3), 171–174. https://doi.org/10.1016/S0304-3940(03)00824-3