Asymmetric hydrogenation of enamides in aqueous media with a new water-soluble chiral rhodium-α,α-trehalose-derived phosphine-phosphinite catalyst

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Abstract

A new chiral rhodium catalyst with α,α-trehalose-derived phosphine-phosphinite (α,α-TREHAPPN) ligand, [(TREHAPPN)Rh(cod)]BF4 8 has been prepared. This catalyst is soluble in water and is an effective chiral catalyst for asymmetric hydrogenation of N-acyldehydroamino acids in aqueous media to give enantiomerically enriched α-amino acid derivatives with R configuration. The simple decantation allows retrieval of the catalyst from the reaction mixture, the recovered catalyst being re-used without marked loss of enantioselectivity. © 2002 Elsevier Science Ltd. All rights reserved.

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Ohe, K., Morioka, K., Yonehara, K., & Uemura, S. (2002). Asymmetric hydrogenation of enamides in aqueous media with a new water-soluble chiral rhodium-α,α-trehalose-derived phosphine-phosphinite catalyst. Tetrahedron Asymmetry, 13(19), 2155–2160. https://doi.org/10.1016/S0957-4166(02)00569-4

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