The asymmetric hydrogenation of isophorone in the presence of (S)-proline was reinvestigated in the light of recent papers of Torok et al. and Lambert et al. Beside kinetic resolution of trimethyl cyclohexanone with (S)-proline, the chemo- and diastereoselective hydrogenation of isophorone is the source of optically active trimethyl cyclohexanone, which was proved by reaction rate, GC, GC-MS measurements and preparative experiments. © 2008 Elsevier B.V. All rights reserved.
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