Asymmetric hydrogenation of isophorone in the presence of (S)-proline: Revival of a 20 years old reaction

  • Fodor M
  • Tungler A
  • Vida L
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The asymmetric hydrogenation of isophorone in the presence of (S)-proline was reinvestigated in the light of recent papers of Torok et al. and Lambert et al. Beside kinetic resolution of trimethyl cyclohexanone with (S)-proline, the chemo- and diastereoselective hydrogenation of isophorone is the source of optically active trimethyl cyclohexanone, which was proved by reaction rate, GC, GC-MS measurements and preparative experiments. © 2008 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Asymmetric hydrogenation
  • Diastereoselectivity
  • Enantioselectivity
  • Heterogeneous catalysis
  • Isophorone
  • Pd catalyst
  • Proline chiral auxiliary
  • α,β-Unsaturated ketones

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  • M. Fodor

  • A. Tungler

  • L. Vida

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