The asymmetric hydrogenation of isophorone in the presence of (S)-proline was reinvestigated in the light of recent papers of Torok et al. and Lambert et al. Beside kinetic resolution of trimethyl cyclohexanone with (S)-proline, the chemo- and diastereoselective hydrogenation of isophorone is the source of optically active trimethyl cyclohexanone, which was proved by reaction rate, GC, GC-MS measurements and preparative experiments. © 2008 Elsevier B.V. All rights reserved.
Fodor, M., Tungler, A., & Vida, L. (2009). Asymmetric hydrogenation of isophorone in the presence of (S)-proline: Revival of a 20 years old reaction. Catalysis Today, 140(1–2), 58–63. https://doi.org/10.1016/j.cattod.2008.07.015