An asymmetric synthesis of a 4-substituted-1,4-dihydropyridine

  • Ashworth I
  • Hopes P
  • Levin D
 et al. 
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Abstract

A concise, convergent asymmetric synthesis of the 4-substituted-1,4-dihydropyridine 1 [Ohnmacht, C. J., Jr.; Trainor, D. A.; Forst, J. M.; Stein, M. M.; Harris, R. J. Patent No. 5,622, 964] has been achieved via a novel asymmetric Michael addition of an optically pure vinylogous amide to an α,β-unsaturated ketone. The overall process is three steps from readily available starting materials and provides an economical manufacturing route to the title compound, which was required as a candidate drug for the treatment of urinary incontinence. © 2002 Elsevier Science Ltd. All rights reserved.

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Authors

  • Ian Ashworth

  • Phillip Hopes

  • Danny Levin

  • Ian Patel

  • Rashida Salloo

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