Asymmetric synthesis. XXXIX.1synthesis of 3-substituted piperidin-2-ones from chiral non-racemic lactams

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Abstract

A series of 3-substituted piperidines in enantiomerically pure form has been synthesized from lactam 1 via the bromo derivative 2i. t-Butyl acetate and 5-methylpyridine derivatives 2g and 2h were obtained optically pure by direct alkylation of 1 with corresponding halides. Azido, amino or benzyloxy products were obtained by diastereoselective substitution of 2i. Copyright © 1996 Elsevier Science Ltd.

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Micouin, L., Bonin, M., Cherrier, M. P., Mazurier, A., Tomas, A., Quirion, J. C., & Husson, H. P. (1996). Asymmetric synthesis. XXXIX.1synthesis of 3-substituted piperidin-2-ones from chiral non-racemic lactams. Tetrahedron, 52(22), 7719–7726. https://doi.org/10.1016/S0040-4020(96)00339-0

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