Asymmetric synthesis. XXXIX.1synthesis of 3-substituted piperidin-2-ones from chiral non-racemic lactams

  • Micouin L
  • Bonin M
  • Cherrier M
 et al. 
  • 5

    Readers

    Mendeley users who have this article in their library.
  • 17

    Citations

    Citations of this article.

Abstract

A series of 3-substituted piperidines in enantiomerically pure form has been synthesized from lactam 1 via the bromo derivative 2i. t-Butyl acetate and 5-methylpyridine derivatives 2g and 2h were obtained optically pure by direct alkylation of 1 with corresponding halides. Azido, amino or benzyloxy products were obtained by diastereoselective substitution of 2i. Copyright © 1996 Elsevier Science Ltd.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Laurent Micouin

  • Martine Bonin

  • Marie Pierre Cherrier

  • Alain Mazurier

  • Alain Tomas

  • Jean Charles Quirion

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free