Asymmetric synthesis. XXXIX.1synthesis of 3-substituted piperidin-2-ones from chiral non-racemic lactams

  • Micouin L
  • Bonin M
  • Cherrier M
 et al. 
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A series of 3-substituted piperidines in enantiomerically pure form has been synthesized from lactam 1 via the bromo derivative 2i. t-Butyl acetate and 5-methylpyridine derivatives 2g and 2h were obtained optically pure by direct alkylation of 1 with corresponding halides. Azido, amino or benzyloxy products were obtained by diastereoselective substitution of 2i. Copyright © 1996 Elsevier Science Ltd.

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  • Laurent Micouin

  • Martine Bonin

  • Marie Pierre Cherrier

  • Alain Mazurier

  • Alain Tomas

  • Jean Charles Quirion

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