Auditory startle in Swiss Webster mice fed excess aluminum in diet

  • Golub M
  • Han B
  • Keen C
 et al. 
  • 1

    Readers

    Mendeley users who have this article in their library.
  • 14

    Citations

    Citations of this article.

Abstract

Using an automated method, reduced auditory startle responsiveness was detected in Swiss Webster mice fed excess aluminum in diet (1000 μg Al/g) as compared to controls (7 μg Al/g). Excess aluminum diets were fed either from conception to weaning (developmental group) or from conception and continuing to 52 days of age (continuous group). At 22 days of age, lower response amplitudes were seen in the aluminum exposed groups than in controls. At 52 days of age, more rapid reduction in response amplitude across initial trial blocks was noted. Effects were more prominent in the continuously exposed than the developmentally exposed group at 52 days of age. Reduced auditory startle responsiveness is interpreted as part of a pattern of subtle motor impairment and marginally reduced activity and responsiveness in mice fed excess aluminum in diet. © 1994.

Author-supplied keywords

  • Aluminum
  • Auditory startle
  • Habituation
  • Mice

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Mari S. Golub

  • Bin Han

  • Carl L. Keen

  • M. Eric Gershwin

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free