Augmentation of delayed-type hypersensitivity reactions to ovalbumin by cyclophosphamide in the mouse: Strain variability, antigen specificity and nature of the suppressor cell

  • Thomson A
  • Nelson D
  • Moon D
  • 1


    Mendeley users who have this article in their library.
  • 8


    Citations of this article.


The use of complete Freund's adjuvant (CFA) or pretreatment with cyclophosphamide (Cy) resulted in augmented delayed-type hypersensitivity (DTH) reactions in mice immunized with ovalbumin (OVA) and challenged 8 days later with heat-aggregated antigen. In 7 different strains, the degree of enhancement of DTH ranged from 2.5 to 4.2-fold with CFA and from 1.2 to 3.6-fold with Cy. More intense 24-h reactions (increased 3.3–8.8-fold) were elicited by use of both Cy and CFA. The effect of Cy was reversed by systemic transfer (at the time of immunization) of immune spleen cells, but not by cells treated with anti-Thy-1.2 and complement. The capacity of the suppressor T cells to reverse the potentiating effect of the drug was antigen-specific. © 1983, All rights reserved.

Author-supplied keywords

  • Antigènes agrégés par la chaleur, Souris, Adjuvant, Cellules suppressives
  • Cyclophosphamide, Delayed-type hypersensitivity, Ovalbumin
  • Cyclophosphamide, Hypersensibilité de type retardé, Ovalbumine
  • Heat-aggregated antigens, Mouse, adjuvant, Suppressor cells

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • A. W. Thomson

  • D. S. Nelson

  • D. K. Moon

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free