Azido analogs of acridine: Photoaffinity probes for frameshift mutagenesis in Salmonella typhimurium

  • Firth W
  • Rock S
  • Brown B
 et al. 
  • 2


    Mendeley users who have this article in their library.
  • 10


    Citations of this article.


In order to identify a photoaffinity probe for 9-aminoacridine frameshift mutagenesis, 20 azido analogs of acridine were synthesized and tested in Ames' Salmonella tester strains, TA1535, TA1537, TA1538 and their corresponding excision-repair-proficient strains TA1975, TA1977, and TA1978, to determine their mutagenicity and toxicity relative to 9-aminoacridine. The substituent-mutagenicity patterns observed for these compounds agree very well with those obtained previously for non-azidoacridines. The results presented here show that the 2-azido-analog of 9-aminoacridine demonstrates biological activity similar to 9-aminoacridine prior to photolytic activation. With light activation, however, the 9-amino-2-azido derivative becomes more effective at producing frameshift mutations characteristics of 9-aminoacridine. Furthemore, this photolytic enhancement of mutagenesis appears to be due to the repairable lesion suggesting that covalent attachment of the drug occurs. © 1981.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • William J. Firth

  • S. Grace Rock

  • Brenda R. Brown

  • Lerena W. Yielding

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free