Azido analogs of acridine: Photoaffinity probes for frameshift mutagenesis in Salmonella typhimurium

10Citations
Citations of this article
3Readers
Mendeley users who have this article in their library.
Get full text

Abstract

In order to identify a photoaffinity probe for 9-aminoacridine frameshift mutagenesis, 20 azido analogs of acridine were synthesized and tested in Ames' Salmonella tester strains, TA1535, TA1537, TA1538 and their corresponding excision-repair-proficient strains TA1975, TA1977, and TA1978, to determine their mutagenicity and toxicity relative to 9-aminoacridine. The substituent-mutagenicity patterns observed for these compounds agree very well with those obtained previously for non-azidoacridines. The results presented here show that the 2-azido-analog of 9-aminoacridine demonstrates biological activity similar to 9-aminoacridine prior to photolytic activation. With light activation, however, the 9-amino-2-azido derivative becomes more effective at producing frameshift mutations characteristics of 9-aminoacridine. Furthemore, this photolytic enhancement of mutagenesis appears to be due to the repairable lesion suggesting that covalent attachment of the drug occurs. © 1981.

Cite

CITATION STYLE

APA

Firth, W. J., Rock, S. G., Brown, B. R., & Yielding, L. W. (1981). Azido analogs of acridine: Photoaffinity probes for frameshift mutagenesis in Salmonella typhimurium. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 81(3), 295–309. https://doi.org/10.1016/0027-5107(81)90118-4

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free