The bee venom melittin induces lysis of arthropod granular cells and inhibits activation of the prophenoloxidase-activating system

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Abstract

The bee venom melittin induced degranulation and lysis of isolated granular cells from freshwater crayfish at a concentration of 3.5 μM. Melittin also efficiently blocked β1,3-glucan activation of the prophenoloxidase-activating system present in the blood cells of arthropods. Therefore, it is suggested that melittin in the bee venom may function as a toxin towards parasitic or predatory insects on bees and the bee community. © 1985.

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Söderhäll, K. (1985). The bee venom melittin induces lysis of arthropod granular cells and inhibits activation of the prophenoloxidase-activating system. FEBS Letters, 192(1), 109–112. https://doi.org/10.1016/0014-5793(85)80053-3

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