The acute behavioral effects of PCP, given intravenously in doses of .25, .50, 1.00, 2.50 and 5.00 mg/kg, were examined in 8 male mongrel dogs tested in an open field arena. All doses produced an initial "eyes open" coma accompanied by tremors, rigidity, jerky limb movements, nystagmus, excessive salivation, head weaving, stiff tail, and stereotyped sniffing. In addition, doses of 1.0 mg/kg and above produced jaw snapping, opisthothonus and clonic/tonic seizures. Following recovery from coma, animals evinced pronounced hyperactivity and stereotyped circling. In contrast to other laboratory animal species, the behavioral effects produced by PCP in the dog are strikingly similar to those reported to occur in humans after PCP administration, suggesting that this species may provide an excellent laboratory animal model for studying PCP toxicity. © 1981.
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