Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol

Citations of this article
Mendeley users who have this article in their library.
Get full text


Chronic administration for 16 days of haloperidol (in increasing doses up to 20 mg/kg/day) results in a supersensitivity of dopamine receptors. This supersensitivity is manifested by an enhanced stereotypy and aggression in response to small, otherwise ineffective, doses of apomorphine. Maximum aggression is observed 7 days after the last dose of haloperidol when 2.5 mg/Kg of apomorphine is administered. In addition, "wet shakes", reminiscent of withdrawal from morphine, are observed in these animals after the cessation of the haloperidol administration. These shakes are blocked by morphine. These results may be interpreted to mean that "wet shakes" and drug induced aggression are the results of hyperactivity of the dopaminergic system. © 1974.




Gianutsos, G., Drawbaugh, R. B., Hynes, M. D., & Lal, H. (1974). Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol. Life Sciences, 14(5), 887–898.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free