Binding studies in the lurcher mutant suggest an uneven distribution of putative benzodiazepine receptor subclasses in the mouse cerebellum

  • Sauer G
  • Wille W
  • Müller W
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Abstract

Binding studies using [3H]flunitrazepam in the cerebellum of normal and Lurcher mutant mice indicate that about 90% of the total benzodiazepine receptor population reside on the Purkinje and granule cells. Moreover, the specific binding of the BZ1receptor subclass specific ligand [3H]propyl-β-carboline-3-carboxylate suggests that neuronal elements of the mouse cerebellum other than the Purkinje and granule cells contain about 18% of the BZ1receptors but only about 7% of the BZ2receptors of the mouse cerebellum. © 1984.

Author-supplied keywords

  • Lurcher mutant
  • benzodiazepine receptors
  • cerebellum
  • receptor subclasses distribution

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Authors

  • Gabriele Sauer

  • Wolfgang Wille

  • Walter E. Müller

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