Binding studies in the lurcher mutant suggest an uneven distribution of putative benzodiazepine receptor subclasses in the mouse cerebellum

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Abstract

Binding studies using [3H]flunitrazepam in the cerebellum of normal and Lurcher mutant mice indicate that about 90% of the total benzodiazepine receptor population reside on the Purkinje and granule cells. Moreover, the specific binding of the BZ1receptor subclass specific ligand [3H]propyl-β-carboline-3-carboxylate suggests that neuronal elements of the mouse cerebellum other than the Purkinje and granule cells contain about 18% of the BZ1receptors but only about 7% of the BZ2receptors of the mouse cerebellum. © 1984.

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Sauer, G., Wille, W., & Müller, W. E. (1984). Binding studies in the lurcher mutant suggest an uneven distribution of putative benzodiazepine receptor subclasses in the mouse cerebellum. Neuroscience Letters, 48(3), 333–338. https://doi.org/10.1016/0304-3940(84)90060-0

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