Biophysical mechanism of the scavenger site near T cell-presented epitopes

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Abstract

We seek to identify consensus sequences in digested fragments of antigenic proteins regulating selection and major histocompatibility complex (MHC)-restricted presentation to T cells of epitopes within those fragments. One such pattern, of recurrent, hydrophobic sidechains forming a longitudinal hydrophobic strip when a sequence is coiled as an α-helix, is found in or near most T cell-presented epitopes. Such recurrent hydrophobicity may lead to protease-protected coiling of the fragment against endosomal membranes and transfer to MHC molecules. This concept leads to better identification of T cell-presented sequences and possibly to engineering of T cell-presented vaccines to affect their potency and MHC restriction. © 1992.

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Lu, S., Reyes, V. E., Bositis, C. M., Goldschmidt, T. G., Lam, V., Torgerson, R. R., … Humphreys, R. E. (1992). Biophysical mechanism of the scavenger site near T cell-presented epitopes. Vaccine. https://doi.org/10.1016/0264-410X(92)90410-L

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