Biosynthesis of gibberellins A12, A15, A24, A36, and A37by a cell-free system from Cucurbita maxima

  • Graebe J
  • Hedden P
  • Gaskin P
 et al. 
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GA12-aldehyde obtained from mevalonate via ent-kaurene, ent-kaurenol, ent-kaurenoic acid and ent-7α-hydroxykaurenoic acid in a cell-free system from immature seeds of Cucurbita maxima was converted to GA12by the same system. When Mn2+was omitted from the system GA12-aldehyde and GA12were converted further to several products. Among these GA15, GA24, GA36and GA37were conclusively identified by GC-MS. With the exception of GA37these GAs have not previously been found in higher plants. Another biosynthetic pathway led from ent-7α-hydroxykaurenoic acid to very polar products via what was tentatively identified as ent-6α, 7α-dihydroxykaurenoic acid. An unidentified component with an MS resembling that of a dihydroxykaurenolide was also obtained from incubations with mevalonate. © 1974.

Author-supplied keywords

  • Cucurbita maxima
  • Cucurbitaceae
  • biosynthesis
  • cell-free system
  • diterpenoids.
  • gibberellins

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  • Jan E. Graebe

  • Peter Hedden

  • Paul Gaskin

  • Jake MacMillan

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