Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist

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Abstract

The ability of a selective neuromedin B receptor antagonist, D-Nal-cyclo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2(BIM-23127), to block suppression of food intake produced by the mammalian bombesin-like peptides neuromedin B and neuromedin C was examined. BIM-23127 completely blocked suppression of intake produced by neyromedin B but not by neuromedin C. These results suggest an independent role for neuromedin B receptors in suppression of food intake by bombesin-like peptides and demonstrate the utility of this group of antagonists for in vivo experiments. © 1994.

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Ladenheim, E. E., Taylor, J. E., Coy, D. H., & Moran, T. H. (1994). Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist. European Journal of Pharmacology, 271(1). https://doi.org/10.1016/0014-2999(94)90291-7

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