Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist

  • Ladenheim E
  • Taylor J
  • Coy D
 et al. 
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Abstract

The ability of a selective neuromedin B receptor antagonist, D-Nal-cyclo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2(BIM-23127), to block suppression of food intake produced by the mammalian bombesin-like peptides neuromedin B and neuromedin C was examined. BIM-23127 completely blocked suppression of intake produced by neyromedin B but not by neuromedin C. These results suggest an independent role for neuromedin B receptors in suppression of food intake by bombesin-like peptides and demonstrate the utility of this group of antagonists for in vivo experiments. © 1994.

Author-supplied keywords

  • Bombesin
  • Gastrin-releasing peptide
  • Neuromedin B

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Authors

  • Ellen E. Ladenheim

  • John E. Taylor

  • David H. Coy

  • Timothy H. Moran

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