Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice

24Citations
Citations of this article
5Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Ginseng total saponin (GTS) inhibited methamphetamine-induced hyperactivity and conditioned place preference (CPP). Dopamine (DA) receptor supersensitivity was developed in methamphetamine-induced CPP mice and it was inhibited by GTS. GTS also inhibited apomorphine-induced climbing behavior, showing the antidopaminergic activity of GTS. These results suggest that GTS inhibition of the methamphetamine-induced hyperactivity and CPP may be closely related with the inhibition of dopaminergic activation induced by methamphetamine.

Cite

CITATION STYLE

APA

Kim, H. S., Jang, C. G., Park, W. K., Oh, K. W., Rheu, H. M., Cho, D. H., & Oh, S. (1996). Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice. General Pharmacology, 27(2), 199–204. https://doi.org/10.1016/0306-3623(95)02023-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free