Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice

  • Kim H
  • Jang C
  • Park W
 et al. 
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Abstract

Ginseng total saponin (GTS) inhibited methamphetamine-induced hyperactivity and conditioned place preference (CPP). Dopamine (DA) receptor supersensitivity was developed in methamphetamine-induced CPP mice and it was inhibited by GTS. GTS also inhibited apomorphine-induced climbing behavior, showing the antidopaminergic activity of GTS. These results suggest that GTS inhibition of the methamphetamine-induced hyperactivity and CPP may be closely related with the inhibition of dopaminergic activation induced by methamphetamine.

Author-supplied keywords

  • conditioned place preference
  • dopamine receptor supersensitivity
  • hyperactivity
  • methamphetamine
  • panax ginseng

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Authors

  • Hack Seang Kim

  • Choon Gon Jang

  • Woo Kyu Park

  • Ki Wan Oh

  • Hang Mock Rheu

  • Dae Hyun Cho

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