The bovine (Bos taurus) CD11a-encoding cDNA: Molecular cloning, characterisation and comparison with the human and murine glycoproteins

  • Fett T
  • Zecchinon L
  • Baise E
 et al. 
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Abstract

The bovine cDNA encoding CD11a, a cell-surface glycoprotein involved in multiple leukocyte functions, was sequenced and compared with the human and murine sequences. Despite some focal differences, it shares all the main characteristics of its known mammalian homologs. Along with the bovine CD18-encoding cDNA, which is available for a long time, the sequence data provided here will allow the successful expression of bovine CD11a, thus giving the first opportunity to express the Bos taurus β2-integrin CD11a/CD18 (LFA-1, αLβ2) in vitro as a tool to examine the specificities of inflammation in the bovine species. © 2003 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Adhesion
  • Cattle
  • ICAM
  • Integrins
  • LFA-1

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Authors

  • Thomas FettUniversity of Liege Faculty of Veterinary Medicine

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  • L. Zecchinon

  • E. Baise

  • D. Desmecht

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