Bronchiolite folliculaire

  • Perotin J
  • Deslee G
  • Dury S
 et al. 
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Introduction: Follicular bronchiolitis (FB) is a rare type of cellular bronchiolitis characterised by the presence of hyperplastic lymphoid follicles with reactive germinal centres, distributed along the bronchovascular bundles. Observation: A non-smoking 36 year old woman was seen because of progressive exertional dyspnoea for 2 years. Chest x-ray and lung CT scan were normal. Pulmonary function tests revealed irreversible airflow obstruction. Exercise testing showed a ventilatory limitation of aerobic capacity with limitation of volume recruitment. The diagnosis of FB was obtained by surgical biopsy. A deficiency of immunoglobulins G4 and M was found. Conclusion: The main clinical manifestation of FB is exertional dyspnoea in a young patient. The lung CT scan frequently shows peripheral micronodules but a normal scan does not exclude the diagnosis. The main causes of FB are collagen vascular diseases (especially rheumatoid arthritis) and immunodeficiency syndromes. The treatment of FB is not well defined. © 2007 SPLF. Édité par Elsevier Masson SAS.

Author-supplied keywords

  • Airflow obstruction
  • Bronchiolitis

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  • J. M. Perotin

  • G. Deslee

  • S. Dury

  • M. Patey

  • O. Toubas

  • F. Lebargy

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