Sensory neurons isolated from the dorsal root ganglia of embryonic rats and grown in culture are distributed into two populations based on cross-sectional areas and sensitivity to capsaicin. Of the total neuronal population, about 48% of the neurons are labelled by cobalt in the presence of 1 μM capsaicin. The distribution of the small-sized neurons coincides with that of the capsaicin-cobaltlabelled neurons. When a lower concentration of capsaicin (100 nM) is used, pretreatment of sensory neurons with carba prostacyclin, a stable analog of prostaglandin I2, produces a three-fold enhancement in the number of neurons that are cobalt-labelled by capsaicin compared with that in the absence of carba prostacyclin. © 1994.
Hingtgen, C. M., & Nicol, G. D. (1994). Carba prostacyclin enhances the capsaicin-induced cobalt-loading of rat sensory neurons grown in culture. Neuroscience Letters, 173(1–2), 99–102. https://doi.org/10.1016/0304-3940(94)90158-9